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KMID : 0359319940340020339
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Korean Journal of Veterinary Research
1994 Volume.34 No. 2 p.339 ~ p.347
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Pathological findings of paraquat poisoning in mice , rats and rabbits
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Abstract
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This study was carried out to investigate the pathological changes with paraquat(1.1´-dimethyl-4.4´-dipyrildiylium dichloride) administered by intraperitoneally, orally, skin applied in mice, rats and rabbits.
Results were obtained as follows;
In 2 days after paraquat administration clinical signs anorexia, depression, tachypnea, and tachycardia, respiratory failure, coma and death were observed in mice, rats and rabbits. Compared toxicity of paraquat with mouse were observed toward to paraquat that resistance was strong than rats and rabbits. Also, mortality of skin application were found the low than intraperitoneal and high than oral administration.
In the case of gross observation were appear Gps moisture in orally administered rats and rabbits by skin application. Lung of all laboratory animals were observed conl;estion and haemorrhage, swelling or atrophy. In the case of microscopic findings were severe congestion and haennorrhage, interstitial pneumonia of lung. Congestion and haemorrhage of liver, congestion and haemorrhage, renal tubule epithelium necrosis of kidney were observed in mice, rats and rabbits. Skin application group of mice, rats and rabbits showed infiltration of inflammatory cells and folliculitis of epidermis and dermis. Also, in oral administration group showed congestion and haemorrhage,
tachment, necrosis of alimentary tract mucosa.
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KEYWORD
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